The Province of Sindh, Pakistan, faces severe food insecurity due to climatic events like floods and socio-economic crises such as inflation and political instability, with the 5F crisis (rising costs of food, fuel, finance, feed, and fertilizer) particularly undermining food access and agricultural productivity. Anticipatory Action (AA), a pre-shock disaster risk management approach, aims to protect the assets and agency of vulnerable populations, helping them endure crises without falling into hunger or losing their livelihoods. This report explores the potential of using AA to address food insecurity in Sindh driven by socio-economic shocks. Using literature review, interviews with 13 key informants, and a descriptive analysis of FAO’s DIEM survey data from 2021–2024, the study applied Derrida’s Deconstruction method to examine the dynamic between food access and structural vulnerabilities, identifying widespread poverty, informal economies, fragile institutions, outdated agri-food systems, and exclusionary land systems as major constraints, while also acknowledging mutual assistance as a critical coping mechanism. The 5F crisis affects food access by reducing affordability and household purchasing power. While AA has been effective in climate disasters, applying it to slow-onset socio-economic crises is more complex due to prediction challenges and funding constraints. Nevertheless, integrating AA with social protection schemes, focusing on physical asset distribution, involving local actors, and adapting existing government policies for pre-crisis use could make AA more viable. Key challenges include data scarcity, trigger definition, timely funding, and coordination gaps among stakeholders. Recommendations include establishing clear triggers and responsibilities, improving collaboration, emphasizing AA’s relevance, prioritizing physical assets, promoting flexible strategies, engaging local stakeholders, addressing inclusion errors, regulating informal economies, increasing proactive investment, enhancing skill training, and encouraging local food production to build resilience.