This paper aims to facilitate the decision-making process and funds allocation strategy of The Hepatitis Fund by identifying and providing a comprehensive overview of factors that contribute to the catalytic success of hepatitis elimination programmes. Given the current geopolitical context – characterised by reduced aid predictability – implementing cost-effective elimination programmes with long-term impacts beyond the completion cycle of projects is more critical than ever. Drawing on concrete examples from programmes carried out in Egypt, Rwanda, Vietnam, and Pakistan, this paper provides 22 recommendations for designing and selecting hepatitis elimination programmes, based on an in-depth desk review of existing literature combined with interviews with viral hepatitis experts. The results emphasise the importance of political commitment, stakeholder inclusion, context-specific programme adaptations, integration into existing health care services, decentralisation efforts, addressing stigma and reduction of accessibility barriers.