Over the past 20 years, the Global Fund has changed the global health landscape by successfully controlling HIV, TB and malaria, the most devastating epidemics of the developing world. Since 2020, the Covid-19 epidemic has reshuffled the deck and shown health and economic vulnerability and inequity of the global community. It brought new – but not so new - global health issues to the forefront and among them the global pandemic preparedness and response and its financing, rethinking the global health architecture, the flow of international aid, the articulation of health research and development to delivery and programming, and strengthening national health systems. At the same time, the Global Fund is revising its strategy for 2023–2027 and preparing its 7th replenishment to be held in the second half of 2022. This replenishment should be highly impacted by financing Covid-19 response and what will be decided collectively to better prevent and respond to pandemics. This event will be the opportunity to reflect on lessons learned from the fight against HIV, TB and malaria to better prepare for future pandemics and health threats, and on how international organisations for health might evolve in this context.